6PPD is an ozone scavenger used to help protect tires from degradation. While 6PPD does not appear to have significant toxicity, when it reacts with ozone it transforms into several different byproducts, including 6PPD-quinone. A recent study has determined that 6PPD-quinone is highly toxic to coho salmon, resulting in death when exposure to sufficiently high concentrations via stormwater runoff occurs.1 Further work is ongoing to determine how expansive the risk of 6PPD-quinone is to other species of salmon and other aquatic wildlife.

CIL has recently developed 6PPD-quinone standards, including a robust phenyl-13C6-labeled standard, to assist researchers with their testing needs.

Catalog No. Description Concentration Amount
CLM-12293-1.2 6PPD-Quinone (phenyl-13C6, 99%) 100 µg/mL in acetonitrile 1.2 mL
ULM-12288-1.2 6PPD-Quinone (unlabeled) CP 95% 100 µg/mL in acetonitrile 1.2 mL


Please feel free to contact us at envsales@isotope.com to request a quote or for additional information.

Best regards,
Your CIL Team

1. Tian, Z.; Zhao, H.; Peter, K.T.; Gonzalez, M.; et al. 2021. A ubiquitous tire rubber-derived chemical induces acute mortality in coho salmon. Science, 371(6525), 185-189. science.sciencemag.org/content/371/6525/185